According to new research, the chance of SARS-CoV-2 having a natural origin is less than 1 in 100 million.1,2 The paper3 was posted on the preprint server BioRxiv October 20, 2022.
One of its authors, mathematical biologist Alex Washburne, also summarizes the work in a Substack article,4 posted that same day. The other two authors are Valentin Bruttel, a molecular immunologist, and Antonius VanDongen, a pharmacologist. There are two key take-homes from this paper:
- SARS-CoV-2 has a telltale signature of genetic engineering, not previously identified
- That genetic fingerprint also suggests the work of Ralph Baric, Ph.D., was used in the creation of the virus. There’s a direct match between Baric’s published research — in which he describes how to hide telltale signs of genetic engineering — and the genetics found in SARS-CoV-2
Seamless Ligation Conceals Genetic Tampering
In 2002, Baric and three other researchers published a paper5 in the Journal of Virology titled “Systematic Assembly of a Full-Length Infectious cDNA of Mouse Hepatitis Virus Strain A59.” In it, they describe a technique called “seamless ligation,” which conceals all evidence of genetic engineering in lab-created pathogens. Baric’s nickname for this technique is the “no-see’m method.”
The research was funded by two National Institutes of Health grants6 — AI 23946, for studies into the mechanism of MHV (mouse hepatitis virus) replication and SARS reverse genetics,7 and GM 63228, for reverse genetics with a coronavirus infectious cDNA construct.8
Seamless Ligation Leaves Signature of Its Own
However, while seamless ligation conceals human tampering in lab-created pathogens, it turns out the method leaves a signature of its own in the amino acid code, and that’s the signature Washburne and his coauthors discovered in SARS-CoV-2.
In summary, the telltale signature left behind by the no-see’m method are unique and odd “spellings” in the “genetic vocabulary” that you normally do not find in the genome of a natural virus. The lay summary in the paper describes it like this:9
“To construct synthetic variants of natural coronaviruses in the lab, researchers often use a method called in vitro genome assembly. This method utilizes special enzymes called restriction enzymes to generate DNA building blocks that then can be ‘stitched’ together in the correct order of the viral genome.
To make a virus in the lab, researchers usually engineer the viral genome to add and remove stitching sites, called restriction sites. The ways researchers modify these sites can serve as fingerprints of in vitro genome assembly.”
In an October 21, 2022, Defender article, Robert F. Kennedy Jr., Jay Couey, Ph.D., and Charles Rixey clarified the findings as follows:10
“The magic of Baric’s ‘no-see’m’ technique is to invisibly weave these telltale ‘spelling’ changes into the viral sequence between relevant genes without altering the viral protein. This is like changing the ‘spelling’ of the word without changing its meaning; the casual listener will never notice the difference.
The research team used forensic tools to drill down on minute ‘spelling differences’ in the SARS-CoV2 genome that betray laboratory tampering using the ‘no-see’m’ technique.
Consider how a Brit would spell ‘colour,’ ‘manoeuvre’ or ‘paediatric.’ The choice to spell a word in a certain way can reveal your nation of origin. Similarly, these nearly imperceptible changes in the viral sequence give away the laboratory origins of this virus.”
Regularly Spaced Cutting Sites Reveal Manipulation
They were able to identify the signature left behind by seamless ligation by plotting the distribution of cutting sites on the SARS-CoV-2 virus and then comparing it to the distribution of cutting sites on wild-type SARS viruses and other lab-created SARS viruses.
Wild-type SARS viruses had cutting sites that were randomly distributed. Lab-created SARS viruses, on the other hand — and SARS-CoV-2 — had regularly spaced cutting sites. According to the authors, that’s a clear indication that SARS-CoV-2 was manipulated in the lab using Baric’s no-see’m technique.
Another telltale sign of human manipulation is the length between the cutting sites. The longest segments found in wild-type viruses were found to be far longer than those found in lab-made viruses, including SARS-CoV-2.
The reason for this is because lab-made viruses are stitched together from smaller pieces, so the genetic segments tend to be short. In nature, however, the lengths of the segments are completely random and include both very short, medium and very long segments.
The types of mutations in SARS-CoV-2 also didn’t conform to what you see in wild-type, naturally evolved viruses. So, SARS-CoV-2 looks like a lab creation in more ways than one. As noted in their lay summary:11
“We found that SARS-CoV has the restriction site fingerprint that is typical for synthetic viruses. The synthetic fingerprint of SARS-CoV-2 is anomalous in wild coronaviruses, and common in lab-assembled viruses.
The type of mutations (synonymous or silent mutations) that differentiate the restriction sites in SARS-CoV-2 are characteristic of engineering, and the concentration of these silent mutations in the restriction sites is extremely unlikely to have arisen by random evolution.
Both the restriction site fingerprint and the pattern of mutations generating them are extremely unlikely in wild coronaviruses and nearly universal in synthetic viruses. Our findings strongly suggest a synthetic origin of SARS-CoV-2.”
Genetic Fingerprints Point Directly at Baric, Fauci and the WIV
According to Washburne and his coauthors, this artifact in the amino acid code of SARS-CoV-2 could only have emerged through the use of Baric’s seamless ligation (no see’m) method.
That’s bad news for Baric, who created the method, and Dr. Anthony Fauci, who funded the development of the technique through the National Institutes of Allergy and Infectious Diseases (NIAID). It also incriminates Shi Zhengli, aka “the Bat Lady” at the Wuhan Institute of Virology. As reported by Kennedy:12
“Baric taught his ‘no-see’m’ method to … Shi Zhengli in 2016. In return, Baric received Chinese coronaviruses collected by Shi from bats in Yunnan province. (Scientists have linked the COVID-19 genome’s pedigree to closely related bats.)…